K.Barry Sharpless

2001 Nobel Prize in Chemistry | Scripps Institute, United States


Barry Sharpless is an American chemist known for his work on stereoselective reactions. He was awarded a half-share of the Nobel Prize in Chemistry in 2001 for his work on stereoselective oxidation reactions (Sharpless epoxidation, Sharpless asymmetric dihydroxylation, Sharpless oxyamination). The other half of the year's Prize was shared between William S. Knowles and Ryōji Noyori (for their work on stereoselective hydrogenation). He also successfully epoxidized (using racemic tartaric acid) a C-86 Buckminster Fullerene ball, employing p-Cresol as solvent. More recently he has been an important figure in the new field of click chemistry. This involves a set of highly selective, exothermic reactions which occur under mild conditions; the most successful example is the azide alkyne Huisgen cycloaddition to form 1,2,3-triazoles.

[Video] Click Chemistry: Recent Advances Used in Biomedicine Presentation at the Molecular Frontiers Symposium in Singapore 2012

Photo by Per Thorén

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